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VACCINES & IMMUNISATION

Active & passive immunising agents

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No drugs in Vaccines & Immunisation matched.

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Emergency Antidotes Protocol

Rapid toxicology reversal reference

Opioids (Morphine, Fentanyl)↳ Naloxone

0.4–2 mg IV/IM/IN q2-3m

Benzodiazepines↳ Flumazenil

0.2 mg IV over 30s

Acetaminophen (Paracetamol)↳ N-Acetylcysteine

150 mg/kg IV loading

Heparin (UFH)↳ Protamine Sulfate

1 mg per 100 U heparin

Warfarin↳ Vitamin K₁ / 4F-PCC

10 mg IV + 25-50 U/kg PCC

Digoxin Toxicity↳ DigiFab

Equimolar binding vials

Beta-Blocker Overdose↳ Glucagon + High-Dose Insulin

5–10 mg IV bolus + HDI

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Pregnancy Risk Categories

SafeControlled human studies show no fetal risk in any trimester.

Likely SafeAnimal studies show no risk, or human safety confirmed.

CautionAdverse fetal effects in animals; weigh risk vs therapeutic benefit.

Human RiskInvestigational data show risk; reserve for life-threatening scenarios.

ContraindicatedProven fetal abnormalities; absolute contraindication in pregnancy.

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CYP450 Major Interactions

CYP3A4

Substrates:Statins, CCBs, Macrolides

Inducers:Rifampin, St. John's Wort, Carbamazepine

Inhibitors:Ketoconazole, Clarithromycin, Grapefruit

CYP2D6

Substrates:Codeine, Beta-blockers, SSRIs

Inducers:Dexamethasone, Rifampin

Inhibitors:Fluoxetine, Paroxetine, Quinidine

CYP2C9

Substrates:Warfarin, Phenytoin, NSAIDs

Inducers:Rifampin, Phenobarbital

Inhibitors:Amiodarone, Fluconazole, Bactrim

MEDICAL DISCLAIMER — This content is intended for educational purposes and qualified healthcare professionals only. Always refer to current prescribing information and official clinical guidelines. Medobo is not responsible for clinical decisions made based on this content.