Primary Causes & Pathophysiology
Mucosal breach (lining break) exposes vessels to acid and pepsin (stomach juices). Erosion into an artery causes brisk fresh bleeding with clots. Portal hypertension (high vein pressure) ruptures oesophageal or gastric varices (swollen veins) with massive bleed. Slow oozing altered by acid forms haematin (dark pigment) seen as coffee-ground. Volume loss cuts preload (heart fill) and causes shock (poor organ flow).
Ulcer erodes through mucosa (lining) into a submucosal artery so arterial bleeding vomits as fresh blood
High portal pressure dilates veins that rupture under thin wall tension causing massive fresh bleed
Forceful retching splits mucosa (lining tear) after vomiting and bleeds from small arterial vessels
Diffuse chemical injury from acid, alcohol or drugs breaks barrier and oozes from many surface points
Reflux or pill injury ulcerates gullet lining (food pipe skin) exposing fragile vessels that bleed when vomiting
Tumour neovessels (new fragile vessels) bleed easily and ulcerated tumour oozes with retching
Abnormally large artery sits just under mucosa (thin cover) and bursts through a tiny defect with brisk bleed