Primary Causes & Pathophysiology
Electrocardiography detects the extracellular potential differences generated by myocardial cells during depolarization and repolarization. When cardiac muscle cells depolarize, sodium ions enter the cell, creating an electrical dipole that spreads through the myocardium. The body surface electrodes detect the sum of these dipoles from different orientations, producing the P wave (atrial depolarization), QRS complex (ventricular depolarization), and T wave (ventricular repolarization). The timing and morphology of these waveforms reflect the sequence and speed of electrical conduction through the atria, atrioventricular node, His-Purkinje system, and ventricles. Abnormalities in electrolyte concentrations, myocardial ischaemia, or conduction tissue disease alter these potentials and produce characteristic ECG patterns.